hippocampus anatomy histology subiiculum

In addition to the memory function, the hippocampus subserves spatiotemporal orientation. Subicular neurons send their axons mainly to the EC. The disruption of this circuit by decline of neurons of the entorhinal cortex is a hallmark of human Alzheimer’s disease which leads to a loss of the short-term and long-term memory. Pyramidal cells of CA1 send their axons to the subiculum and deep layers of the EC. It is part of a functionally very important circuit for the short-term and long-term memory starting in the neighboring entorhinal cortex via the dentate gyrus and Cornu Ammonis back to the entorhinal cortex (classical trisynaptic pathway). We are currently pursuing three projects related to cellular diversity in the hippocampus (see right-side menu). Conclusion: In vivo 7T MR imaging can take advantage of higher signal-to-noise and novel contrast mechanisms to provide increased conspicuity of hippocampal anatomy. Even within CA1 and subiculum (the major output structures of the hippocampus), we have found two distinct types of pyramidal neurons, which differ in their morphology, physiology and plasticity (Graves et al., 2012). SWI im-ages (0.5 mm in-plane resolution, 1.0 mm slice thickness) delineated microvenous anatomy of the hippocampus. 10), the hippocampus consists mainly of three layers and can roughly be subdivided into the dentate gyrus and the Cornu Ammonis. lation of adjacent sublayers of the hippocampus. PMID: 4111738 PubMed - indexed for MEDLINE MeSH Terms. Entorhinal area, parasubiculum, presubiculum, and subiculum. The human hippocampus has a basal position in the telencephalon but, regarding its fine structure, is very much alike that of the rodent hippocampus. The hippocampal formation, which comprises the hippocampus proper, dentate gyrus, and subiculum, is crucial for learning, memory, and spatial navigation. Distribution of aspartate aminotransferase in the hippocampal region of the guinea pig. The rodent hippocampus is a continuous structure that changes its cranial dorsal position to a lateroventral location in the more caudal parts where it eventually reaches the ventral surface of the brain. The hippocampus is the phylogenetically second oldest part of the telencephalon after the olfactory system (Chap.

Hippocampus anatomy histology subiiculum